Adenine protonation enables cyclic-di-GMP binding to cyclic-GAMP sensing riboswitches.
In certain structural or functional contexts, RNA structures can contain protonated nucleotides. However, a direct role for stably protonated nucleotides in ligand binding and ligand recognition has not yet been demonstrated unambiguously. Previous X-ray structures of c-GAMP binding riboswitch aptamer domains in complex with their near-cognate ligand c-di-GMP suggest that an adenine of the riboswitch …
Adenine protonation enables cyclic-di-GMP binding to cyclic-GAMP sensing riboswitches. Read More »