Swine influenza viruses (SIVs), the causal agents of swine influenza, are not only important to control due to the economic losses in the swine industry, but also can be pandemic pathogens. Vaccination is one of the most relevant strategies to control and prevent influenza infection. Current human vaccines against influenza induce strain-specific immunity and annual update is required due to the virus antigenic shift phenomena. Previously, our group has reported the use of conserved hemagglutinin peptides (HA-peptides) derived from H1-influenza virus as a potential multivalent vaccine candidate.
Immunization of swine with these HA-peptides elicited antibodies that recognized and neutralized heterologous influenza viruses in vitro and demonstrated strong hemagglutination-inhibiting activity. In the present work, we cloned one HA-peptide (named NG34) into a plasmid fused with cytotoxic T lymphocyte-associated antigen (CTLA4) which is a molecule that modifies T cell activation and with an adjuvant activity interfering with the adaptive immune response.
The resulting plasmid, named pCMV-CTLA4-Ig-NG34, was administered twice to animals employing a needle-free delivery approach. Two studies were carried out to test the efficacy of pCMV-CTLA4-Ig-NG34 as a potential swine influenza vaccine, one in seronegative and another in seropositive pigs against SIV. The second one was aimed to evaluate whether pCMV-CTLA4-Ig-NG34 vaccination would overcome maternally derived antibodies (MDA). After immunization, all animals were intranasally challenged with an H3N2 influenza strain.
Rabbit anti Treponema pallidum
MBS315086-1mL
MyBiosource
1mL
EUR 850
Rabbit anti Treponema pallidum
MBS315086-5x1mL
MyBiosource
5x1mL
EUR 3645
Rabbit anti Treponema pallidum
MBS315087-1mL
MyBiosource
1mL
EUR 915
Rabbit anti Treponema pallidum
MBS315087-5x1mL
MyBiosource
5x1mL
EUR 3945
Rabbit anti Treponema pallidum
MBS315088-1mL
MyBiosource
1mL
EUR 915
Rabbit anti Treponema pallidum
MBS315088-5x1mL
MyBiosource
5x1mL
EUR 3945
Rabbit anti Treponema pallidum
MBS315089-1mL
MyBiosource
1mL
EUR 915
Rabbit anti Treponema pallidum
MBS315089-5x1mL
MyBiosource
5x1mL
EUR 3945
Treponema Pallidum and Treponema reiter
MBS319616-1mg
MyBiosource
1mg
EUR 455
Treponema Pallidum and Treponema reiter
MBS319616-5x1mg
MyBiosource
5x1mg
EUR 1970
Treponema p17
trp-241
ProSpec Tany
100µg
EUR 165
Description: Recombinant Treponema pallidum p17
Treponema p41
trp-242
ProSpec Tany
100µg
EUR 165
Description: Recombinant Treponema pallidum p41
Treponema p47
trp-243
ProSpec Tany
100µg
EUR 165
Description: Recombinant Treponema pallidum p47
Treponema p15
trp-246
ProSpec Tany
100µg
EUR 165
Description: Recombinant Treponema pallidum p15
Treponema p17
trp-248
ProSpec Tany
100µg
EUR 165
Description: Recombinant Treponema pallidum p17 (Partial)
Treponema p47
trp-249
ProSpec Tany
100µg
EUR 165
Description: Recombinant Treponema pallidum p47 (Partial)
Treponema p15
trp-275
ProSpec Tany
100µg
EUR 165
Description: Recombinant Treponema pallidum p15 (partial)
Treponema TmpA
trp-245
ProSpec Tany
100µg
EUR 165
Description: Recombinant Treponema pallidum TmpA (Partial)
Treponema TmpA
trp-250
ProSpec Tany
100µg
EUR 165
Description: Recombinant Treponema pallidum TmpA
Mouse Anti Treponema Pallidum Monoclonal Antibody
DMABT-51615MT
Creative Diagnostics
0.2 mg
EUR 546
Description: Mouse
Treponema TP0453
trp-255
ProSpec Tany
100µg
EUR 200
Description: Recombinant Treponema pallidum Outer Membrane Protein TP0453
Treponema Mosaic
trp-276
ProSpec Tany
100µg
EUR 200
Description: Recombinant Treponema pallidum Mosaic
Rabbit Anti Treponema Pallidum Polyclonal Antibody
DPBT-66960RT
Creative Diagnostics
1 ml
EUR 567
Description: Rabbit
Treponema pallidum
2121
Virostat
100 ug
EUR 270
Description: This is purified Mouse monoclonal antibody against Treponema pallidum for WB, ELISA.
Treponema pallidum
2123
Virostat
100 ug
EUR 270
Description: TmpA
Treponema pallidum
2124
Virostat
100 ug
EUR 270
Description: TmpA
Treponema pallidum
2125
Virostat
100 ug
EUR 270
Description: p47
Treponema pallidum
2126
Virostat
100 ug
EUR 270
Description: p47
Treponema pallidum
2127
Virostat
100 ug
EUR 270
Description: p47
Treponema pallidum
2128
Virostat
100 ug
EUR 270
Description: p47
Treponema pallidum
2101
Virostat
1 ml
EUR 235
Description: all antigens
Treponema pallidum
8945
Virostat
100 ug
EUR 340
Description: p15
Treponema pallidum
8946
Virostat
100 ug
EUR 340
Description: p17
Treponema pallidum
8947
Virostat
100 ug
EUR 340
Description: p47
Treponema pallidum
8948
Virostat
100 ug
EUR 340
Description: TmpA
Treponema pallidum
MBS373080-01mLConcentrate
MyBiosource
0.1mL(Concentrate)
EUR 220
Treponema pallidum
MBS373080-05mLConcentrate
MyBiosource
0.5mL(Concentrate)
EUR 335
Treponema pallidum
MBS373080-1mLConcentrate
MyBiosource
1mL(Concentrate)
EUR 475
Treponema pallidum
MBS373080-3mLRTU
MyBiosource
3mL(RTU)
EUR 220
Treponema pallidum
MBS373080-7mLRTU
MyBiosource
7mL(RTU)
EUR 335
Treponema pallidum
MBS328023-01mg
MyBiosource
0.1mg
EUR 435
Treponema pallidum
MBS328023-5x01mg
MyBiosource
5x0.1mg
EUR 1865
Treponema pallidum
MBS328024-01mg
MyBiosource
0.1mg
EUR 435
Treponema pallidum
MBS328024-5x01mg
MyBiosource
5x0.1mg
EUR 1865
Treponema pallidum
MBS328025-01mg
MyBiosource
0.1mg
EUR 435
Treponema pallidum
MBS328025-5x01mg
MyBiosource
5x0.1mg
EUR 1865
Treponema pallidum
MBS328026-01mg
MyBiosource
0.1mg
EUR 435
Treponema pallidum
MBS328026-5x01mg
MyBiosource
5x0.1mg
EUR 1865
Treponema pallidum
MBS320157-01mg
MyBiosource
0.1mg
EUR 355
Treponema pallidum
MBS320157-5x01mg
MyBiosource
5x0.1mg
EUR 1500
Treponema pallidum
MBS324145-1mL
MyBiosource
1mL
EUR 320
Treponema pallidum
MBS324145-5x1mL
MyBiosource
5x1mL
EUR 1355
Treponema pallidum
MBS324146-1mL
MyBiosource
1mL
EUR 335
Treponema pallidum
MBS324146-5x1mL
MyBiosource
5x1mL
EUR 1410
Treponema pallidum
MBS324147-1mL
MyBiosource
1mL
EUR 355
Treponema pallidum
MBS324147-5x1mL
MyBiosource
5x1mL
EUR 1500
Treponema pallidum
MBS324148-1mL
MyBiosource
1mL
EUR 335
Treponema pallidum
MBS324148-5x1mL
MyBiosource
5x1mL
EUR 1410
Treponema pallidum
PCR-H456-PCRH45648D
Bioingentech
PCR-H456-48D
EUR 230
Treponema pallidum
PCR-H456-PCRH45696D
Bioingentech
PCR-H456-96D
EUR 312
Treponema pallidum
Oneq-H456-OneqH456100D
Bioingentech
Oneq-H456-100D
EUR 515
Treponema pallidum
Oneq-H456-OneqH456150D
Bioingentech
Oneq-H456-150D
EUR 594
Treponema pallidum
Oneq-H456-OneqH45650D
Bioingentech
Oneq-H456-50D
EUR 413
Treponema pallidum antibody
10-T77A
Fitzgerald
1 mg
EUR 429.6
Description: Mouse monoclonal Treponema pallidum antibody
Treponema pallidum antibody
20C-CR1246RP
Fitzgerald
1 ml
EUR 377
Description: Rabbit polyclonal Treponema pallidum antibody
Treponema pallidum antibody
10R-T135A
Fitzgerald
1 mg
EUR 548.4
Description: Mouse monoclonal Treponema pallidum antibody
Treponema pallidum antibody
20-TG89
Fitzgerald
1 ml
EUR 125
Description: Goat polyclonal Treponema pallidum antibody
Treponema pallidum antibody
20-TR89
Fitzgerald
1 mg
EUR 377
Description: Rabbit polyclonal Treponema pallidum antibody
Treponema pallidum Antibody
abx022285-1mg
Abbexa
1 mg
EUR 1195.2
Treponema pallidum Antibody
abx022285-400l
Abbexa
400 µl
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Treponema pallidum Antibody
abx022285-80l
Abbexa
80 µl
EUR 1200
Treponema pallidum Antibody
abx022286-1mg
Abbexa
1 mg
EUR 1195.2
Treponema pallidum Antibody
abx022288-1mg
Abbexa
1 mg
EUR 1195.2
Treponema pallidum Antibody
abx023196-1ml
Abbexa
1 ml
EUR 777.6
Treponema pallidum Antibody
abx023196-400l
Abbexa
400 µl
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Treponema pallidum Antibody
abx023196-80l
Abbexa
80 µl
EUR 1150
Treponema Pallidum Antibody
abx023643-1mg
Abbexa
1 mg
EUR 718.8
Treponema Pallidum Antibody
abx023644-1mg
Abbexa
1 mg
EUR 718.8
Treponema Pallidum Antibody
abx023677-1mg
Abbexa
1 mg
EUR 718.8
Treponema pallidum, Antibody
GWB-2277A6
GenWay Biotech
1 mg
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Treponema pallidum Antibody
GWB-FAFEB9
GenWay Biotech
0.1 mg
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Treponema pallidum Antibody
GWB-16039B
GenWay Biotech
0.1 mg
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Treponema pallidum Antibody
GWB-56D269
GenWay Biotech
1 ml
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Treponema Pallidum Antibody
GWB-618137
GenWay Biotech
0.2 mg
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Treponema pallidum Antibody
GWB-62BDEE
GenWay Biotech
1 ml
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Treponema pallidum Antibody
GWB-41631C
GenWay Biotech
1 ml
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Treponema pallidum Antibody
GWB-850CA9
GenWay Biotech
1 ml
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Treponema pallidum Antibody
GWB-C3684E
GenWay Biotech
1 ml
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Treponema pallidum, Antibody
GWB-93C557
GenWay Biotech
1 mg
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Treponema Pallidum Antibody
GWB-E73561
GenWay Biotech
1 ml
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Treponema pallidum antibody
MBS530885-INQUIRE
MyBiosource
INQUIRE
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Treponema pallidum antibody
MBS534420-1mL
MyBiosource
1mL
EUR 235
Treponema pallidum antibody
MBS534420-5x1mL
MyBiosource
5x1mL
EUR 900
Treponema pallidum antibody
MBS536184-1mL
MyBiosource
1mL
EUR 550
Treponema pallidum antibody
MBS536184-5x1mL
MyBiosource
5x1mL
EUR 2320
Treponema pallidum antibody
MBS535151-INQUIRE
MyBiosource
INQUIRE
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Treponema p15 His
trp-247
ProSpec Tany
100µg
EUR 165
Description: Recombinant Treponema pallidum p15 (Partial), His Tag
Treponema p17 16.4kDa
trp-252
ProSpec Tany
100µg
EUR 130
Description: Recombinant Treponema pallidum p17, 16.4 kDa
Treponema p47 47.7kDa
trp-253
ProSpec Tany
100µg
EUR 130
Description: Recombinant Treponema pallidum p47, 47.7kDa
Treponema p17 22kDa
trp-254
ProSpec Tany
100µg
EUR 165
Description: Recombinant Treponema pallidum p17, 22 kDa
Treponema p41 Mosaic
trp-244
ProSpec Tany
100µg
EUR 165
Description: Recombinant Treponema pallidum p41 Mosaic
Treponema TmpA 45kDa
trp-251
ProSpec Tany
100µg
EUR 130
Description: Recombinant Treponema pallidum TmpA , 45 kDa
Treponema pallidum antibody (HRP)
60-T69
Fitzgerald
1 ml
EUR 425
Description: Rabbit polyclonal Treponema pallidum antibody (HRP) conjugated
Treponema pallidum Antibody (HRP)
abx023195-1ml
Abbexa
1 ml
EUR 777.6
Treponema pallidum Antibody (HRP)
abx023195-400l
Abbexa
400 µl
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Treponema pallidum Antibody (HRP)
abx023195-80l
Abbexa
80 µl
EUR 1150
Treponema pallidum antibody (HRP)
MBS534665-1mL
MyBiosource
1mL
EUR 775
Treponema pallidum antibody (HRP)
MBS534665-5x1mL
MyBiosource
5x1mL
EUR 3330
Treponema pallidum P15
MBS596327-1mg
MyBiosource
1mg
EUR 425
Treponema pallidum P15
MBS596327-2mg
MyBiosource
2mg
EUR 700
Treponema pallidum P15
MBS596327-5mg
MyBiosource
5mg
EUR 1505
Treponema pallidum P17
MBS596037-1mg
MyBiosource
1mg
EUR 425
Treponema pallidum P17
MBS596037-2mg
MyBiosource
2mg
EUR 700
Treponema pallidum P17
MBS596037-5mg
MyBiosource
5mg
EUR 1505
Treponema pallidum P47
MBS596066-1mg
MyBiosource
1mg
EUR 425
Treponema pallidum P47
MBS596066-2mg
MyBiosource
2mg
EUR 700
Treponema pallidum P47
MBS596066-5mg
MyBiosource
5mg
EUR 1505
Rabbit Anti Treponema Pallidum Polyclonal Antibody,Biotin
DPBT-66959RT
Creative Diagnostics
1 ml
EUR 659.4
Description: Rabbit
Treponema pallidum antibody (FITC)
60-T68
Fitzgerald
1 ml
EUR 425
Description: Rabbit polyclonal Treponema pallidum antibody (FITC) conjugated
Treponema pallidum Antibody (FITC)
abx023194-1ml
Abbexa
1 ml
EUR 777.6
Treponema pallidum Antibody (FITC)
abx023194-400l
Abbexa
400 µl
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Treponema pallidum Antibody (FITC)
abx023194-80l
Abbexa
80 µl
EUR 1150
Treponema pallidum antibody (FITC)
MBS534599-1mL
MyBiosource
1mL
EUR 720
Treponema pallidum antibody (FITC)
MBS534599-5x1mL
MyBiosource
5x1mL
EUR 3095
recomLine Treponema IgG
MBS191639-20Tests
MyBiosource
20Tests
EUR 840
recomLine Treponema IgG
MBS191639-5x20Tests
MyBiosource
5x20Tests
EUR 3805
recomLine Treponema IgG
MBS191640-20Tests
MyBiosource
20Tests
EUR 840
recomLine Treponema IgG
MBS191640-5x20Tests
MyBiosource
5x20Tests
EUR 3805
Treponema pallidum Antibody (Biotin)
abx023193-1ml
Abbexa
1 ml
EUR 777.6
Treponema pallidum Antibody (Biotin)
abx023193-400l
Abbexa
400 µl
Ask for price
Treponema pallidum Antibody (Biotin)
abx023193-80l
Abbexa
80 µl
EUR 1075
Treponema pallidum Antibody (Biotin)
GWB-E4BAD4
GenWay Biotech
1 ml
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TREPONEMA PALLIDUM MOSAIC
GWB-96D8B3
GenWay Biotech
1 mg
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Treponema pallidum protein
30-1287
Fitzgerald
1 mg
EUR 1195
Description: Purified recombinant Treponema pallidum protein
Treponema pallidum Real-TM
Real Time PCR test for detection of Treponema pallidum
B20-100FRT
Sacace Biotechnologies
100
EUR 560.26
Treponema pallidum (TpN15) Antigen >95%
MBS569151-1mg
MyBiosource
1mg
EUR 655
Treponema pallidum (TpN15) Antigen >95%
MBS569151-5x1mg
MyBiosource
5x1mg
EUR 2760
MAb to Treponema pallidum
MBS310316-1mg
MyBiosource
1mg
EUR 955
MAb to Treponema pallidum
MBS310316-5x1mg
MyBiosource
5x1mg
EUR 4115
Treponema pallidum Monoclonal Antibody
MBS190450-02mg
MyBiosource
0.2mg
EUR 365
Treponema pallidum Monoclonal Antibody
MBS320566-01mg
MyBiosource
0.1mg
EUR 355
Treponema pallidum Monoclonal Antibody
MBS320566-5x01mg
MyBiosource
5x0.1mg
EUR 1500
Treponema pallidum Monoclonal Antibody
MBS320567-01mg
MyBiosource
0.1mg
EUR 355
Treponema pallidum Monoclonal Antibody
MBS320567-5x01mg
MyBiosource
5x0.1mg
EUR 1500
Treponema pallidum Monoclonal Antibody
MBS320568-01mg
MyBiosource
0.1mg
EUR 355
Treponema pallidum Monoclonal Antibody
MBS320568-5x01mg
MyBiosource
5x0.1mg
EUR 1500
Treponema pallidum Monoclonal Antibody
MBS320569-01mg
MyBiosource
0.1mg
EUR 355
Treponema pallidum Monoclonal Antibody
MBS320569-5x01mg
MyBiosource
5x0.1mg
EUR 1500
Treponema pallidum Monoclonal Antibody
MBS320570-01mg
MyBiosource
0.1mg
EUR 355
Treponema pallidum Monoclonal Antibody
MBS320570-5x01mg
MyBiosource
5x0.1mg
EUR 1500
Treponema pallidum Monoclonal Antibody
MBS320571-01mg
MyBiosource
0.1mg
EUR 355
Treponema pallidum Monoclonal Antibody
MBS320571-5x01mg
MyBiosource
5x0.1mg
EUR 1500
Treponema pallidum PCR kit
PCR-H456-48D
Bioingentech
50T
EUR 543.6
Treponema pallidum PCR kit
PCR-H456-96D
Bioingentech
100T
EUR 686.4
Treponema Pallidum antibody ELISA Kit
DEIA1013
Creative Diagnostics
96T
EUR 483
Description: serum, plasma
Treponema phagedenis Treponemal membrane protein B (tmpB)
1-CSB-EP333469THS
Cusabio
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10ug
50ug
100ug
200ug
500ug
1MG
Description: Recombinant Treponema phagedenis Treponemal membrane protein B(tmpB) expressed in E.coli
Treponema pallidum (T. pallidum) Antibody
abx411659-1ml
Abbexa
1 ml
EUR 610.8
Treponema pallidum (T. pallidum) Antibody
abx411659-200g
Abbexa
200 µg
EUR 425
Treponema pallidum (T. pallidum) Antibody
MBS568410-05mL
MyBiosource
0.5mL
EUR 300
Treponema pallidum (T. pallidum) Antibody
MBS568410-5x05mL
MyBiosource
5x0.5mL
EUR 1160
Treponema Pallidum (T. Pallidum) Antibody
MBS569761-1mg
MyBiosource
1mg
EUR 485
Treponema Pallidum (T. Pallidum) Antibody
MBS569761-5x1mg
MyBiosource
5x1mg
EUR 1980
Treponema pallidum Ag Protein
abx061388-05mg
Abbexa
0.5 mg
EUR 1328.4
Treponema pallidum (Syphilis) Antibody (p47)
GWB-T00691
GenWay Biotech
100ug
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Treponema pallidum (Syphilis) Antibody (p47)
GWB-T00693
GenWay Biotech
100ug
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p17 Treponema pallidum protein
30-1288
Fitzgerald
1 mg
EUR 1195
Description: Purified recombinant p17 Treponema pallidum protein
p15 Treponema pallidum protein
30-1289
Fitzgerald
1 mg
EUR 1195
Description: Purified recombinant p15 Treponema pallidum protein
Treponema pallidum p15 protein
30-AT67
Fitzgerald
500 ug
EUR 1390.8
Description: Purified recombinant Treponema pallidum p15 protein
p47 Treponema Pallidum protein
30-AT71
Fitzgerald
1 mg
EUR 595
Description: Purified recombinant p47 Treponema Pallidum protein
p17 Treponema Pallidum protein
30-AT72
Fitzgerald
1 mg
EUR 595
Description: Purified recombinant p17 Treponema Pallidum protein
p15 Treponema Pallidum protein
30-AT75
Fitzgerald
1 mg
EUR 595
Description: Purified recombinant p15 Treponema Pallidum protein
Treponema pallidum p15 protein
30R-AT065
Fitzgerald
100 ug
EUR 295
Description: Purified recombinant Treponema pallidum p15 protein
Treponema pallidum p17 protein
30R-AT066
Fitzgerald
500 ug
EUR 867
Description: Purified recombinant Treponema pallidum p17 protein
Treponema pallidum p47 protein
30R-AT067
Fitzgerald
500 ug
EUR 875
Description: Purified recombinant Treponema pallidum p47 protein
p47 Treponema Pallidum protein
80-1395
Fitzgerald
1 mg
EUR 136
Description: Purified recombinant p47 Treponema Pallidum protein
Treponema Pallidum protein (HRP)
80R-2409
Fitzgerald
1 ml
EUR 500
Description: Purified recombinant Treponema pallidum protein
Treponema pallidum p15 Protein
abx060667-100g
Abbexa
100 µg
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Treponema pallidum p15 Protein
abx060667-10g
Abbexa
10 µg
EUR 1500
Treponema pallidum p15 Protein
abx060667-1mg
Abbexa
1 mg
EUR 1028.4
A complete elimination or significant reduction in the viral shedding was observed within the first week after the challenge in the vaccinated animals from both studies. In addition, no challenged heterologous virus load was detected in the airways of vaccinated pigs. Overall, it is suggested that the pCMV-CTLA4-Ig-NG34 vaccine formulation could potentially be used as a multivalent vaccine against influenza viruses.
Conserved HA-peptide NG34 formulated in pCMV-CTLA4-Ig reduces viral shedding in pigs after a heterosubtypic influenza virus SwH3N2 challenge.
Sowing the Seeds of a Pandemic? Mammalian Pathogenicity and Transmissibility of H1 Variant Influenza Viruses from the Swine Reservoir.
Emergence of genetically and antigenically diverse strains of influenza to which the human population has no or limited immunity necessitates continuous risk assessments to determine the likelihood of these viruses acquiring adaptations that facilitate sustained human-to-human transmission.
As the North American swine H1 virus population has diversified over the last century by means of both antigenic drift and shift, in vivo assessments to study multifactorial traits like mammalian pathogenicity and transmissibility of these emerging influenza viruses are critical. In this review, we examine genetic, molecular, and pathogenicity and transmissibility data from a panel of contemporary North American H1 subtype swine-origin viruses isolated from humans, as compared to H1N1 seasonal and pandemic viruses, including the reconstructed 1918 virus.
We present side-by-side analyses of experiments performed in the mouse and ferret models using consistent experimental protocols to facilitate enhanced interpretation of in vivo data. Contextualizing these analyses in a broader context permits a greater appreciation of the role that in vivo risk assessment experiments play in pandemic preparedness. Collectively, we find that despite strain-specific heterogeneity among swine-origin H1 viruses, contemporary swine viruses isolated from humans possess many attributes shared by prior pandemic strains, warranting heightened surveillance and evaluation of these zoonotic viruses.