In this review, we identify opportunities for drug discovery in the treatment of COVID-19 and in so doing, provide a rational roadmap whereby pharmacology and pharmacologists can mitigate against the global pandemic. We assess the scope for targetting key host and viral targets in the mid-term, by first screening these targets against drugs already licensed; an agenda for drug re-purposing, which should allow rapid translation to clinical trials.
A simultaneous, multi-pronged approach using conventional drug discovery methodologies aimed at discovering novel chemical and biological means targetting a short-list of host and viral entities should extend the arsenal of anti-SARS-CoV-2 agents.
p38 protein |
E20-80079 |
EnoGene |
20ug |
EUR 489.6 |
p38 Antibody |
48644-100ul |
SAB |
100ul |
EUR 399.6 |
p38 Antibody |
48644-50ul |
SAB |
50ul |
EUR 286.8 |
p38 antibody |
70R-51505 |
Fitzgerald |
100 ul |
EUR 321.6 |
Description: Purified Polyclonal p38 antibody |
p38 antibody |
70R-51506 |
Fitzgerald |
100 ul |
EUR 344.4 |
Description: Purified Polyclonal p38 antibody |
p38 Antibody |
abx236076-100ug |
Abbexa |
100 ug |
EUR 577.2 |
|
p38 Antibody |
20-abx141038 |
Abbexa |
-
EUR 427.20
-
EUR 644.40
-
EUR 260.40
|
|
|
p38 Antibody |
35478-100ul |
SAB |
100ul |
EUR 468 |
p38 Antibody |
20-abx007541 |
Abbexa |
-
EUR 360.00
-
EUR 526.80
-
EUR 226.80
|
|
|
p38 Antibody |
20-abx133223 |
Abbexa |
-
EUR 360.00
-
EUR 526.80
-
EUR 226.80
|
|
|
SB-203580 p38 MAPK(p38 MAP kinase) Inhibitor |
E1B1863 |
EnoGene |
1mg |
EUR 193.2 |
anti-Crk p38 |
YF-PA11088 |
Abfrontier |
50 ul |
EUR 435.6 |
Description: Mouse polyclonal to Crk p38 |
anti-Crk p38 |
YF-PA11089 |
Abfrontier |
50 ug |
EUR 435.6 |
Description: Mouse polyclonal to Crk p38 |
anti-Crk p38 |
YF-PA11090 |
Abfrontier |
100 ug |
EUR 483.6 |
Description: Rabbit polyclonal to Crk p38 |
anti-Crk p38 |
YF-PA23509 |
Abfrontier |
50 ul |
EUR 400.8 |
Description: Mouse polyclonal to Crk p38 |
p38 beta, Active |
7763-100 |
Biovision |
each |
EUR 5214 |
p38 beta, Active |
7763-5 |
Biovision |
each |
EUR 444 |
p38 beta protein |
30R-2875 |
Fitzgerald |
5 ug |
EUR 603.6 |
Description: Purified recombinant Human p38 beta protein |
Crk Antibody p38 |
R31526 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
Description: CRK, also known as p38, is a protein that in humans is encoded by the CRK gene. This gene is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It is mapped to 17p13.3. The protein participates in the Reelin signaling cascade downstream of DAB1. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of Crk functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
anti-AIMP2/p38 |
YF-PA15507 |
Abfrontier |
50 ug |
EUR 435.6 |
Description: Mouse polyclonal to AIMP2/p38 |
p38 MAPK Antibody |
49379-100ul |
SAB |
100ul |
EUR 399.6 |
p38 MAPK Antibody |
49379-50ul |
SAB |
50ul |
EUR 286.8 |
p38 MAPK antibody |
10R-8422 |
Fitzgerald |
100 ul |
EUR 471.6 |
Description: Mouse monoclonal p38 MAPK antibody |
p38 MAPK antibody |
70R-33398 |
Fitzgerald |
100 ug |
EUR 392.4 |
Description: Rabbit polyclonal p38 MAPK antibody |
p38 MAPK antibody |
70R-33400 |
Fitzgerald |
100 ug |
EUR 392.4 |
Description: Rabbit polyclonal p38 MAPK antibody |
P38 MAPK antibody |
70R-34325 |
Fitzgerald |
100 ug |
EUR 392.4 |
Description: Rabbit polyclonal P38 MAPK antibody |
P38 MAPK antibody |
70R-34327 |
Fitzgerald |
100 ug |
EUR 392.4 |
Description: Rabbit polyclonal P38 MAPK antibody |
p38 MAPK Antibody |
abx236077-100ug |
Abbexa |
100 ug |
EUR 577.2 |
|
P38 MAPK antibody |
20R-2403 |
Fitzgerald |
50 ug |
EUR 337.2 |
Description: Rabbit polyclonal P38 MAPK antibody |
p38 MAPK antibody |
20R-2950 |
Fitzgerald |
100 ul |
EUR 471.6 |
Description: Rabbit polyclonal p38 MAPK antibody |
p38 MAPK antibody |
20R-1572 |
Fitzgerald |
100 ug |
EUR 846 |
Description: Rabbit polyclonal p38 MAPK antibody |
P38 MAPK antibody |
20R-2087 |
Fitzgerald |
50 ug |
EUR 337.2 |
Description: Rabbit polyclonal P38 MAPK antibody |
P38 MAPK antibody |
20R-2088 |
Fitzgerald |
50 ug |
EUR 337.2 |
Description: Rabbit polyclonal P38 MAPK antibody |
P38 delta protein |
30R-2868 |
Fitzgerald |
5 ug |
EUR 603.6 |
Description: Purified recombinant Human P38 delta protein |
p38 alpha protein |
30R-2870 |
Fitzgerald |
5 ug |
EUR 603.6 |
Description: Purified recombinant Human p38 alpha protein |
p38 MAPK Antibody |
20-abx012798 |
Abbexa |
-
EUR 376.80
-
EUR 117.60
-
EUR 477.60
-
EUR 594.00
|
- 100 ug
- 10 ug
- 200 ug
- 300 µg
|
|
p38 MAPK Antibody |
20-abx012875 |
Abbexa |
-
EUR 376.80
-
EUR 117.60
-
EUR 477.60
-
EUR 594.00
|
- 100 ug
- 10 ug
- 200 ug
- 300 µg
|
|
anti- p38 antibody |
FNab06076 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against p38 |
p38 MAPK Antibody |
R20266-0.1ML |
NSJ Bioreagents |
100ul |
EUR 347.65 |
Description: This recombinant p38 antibody reacts to human p38 MAPK. It may also react to the rat and mouse protein, as predicted by immunogen homology. |
p38 (pY182) Antibody |
20-abx134951 |
Abbexa |
-
EUR 460.80
-
EUR 727.20
-
EUR 276.00
|
|
|
p38 (pY323) Antibody |
20-abx133058 |
Abbexa |
-
EUR 376.80
-
EUR 560.40
-
EUR 243.60
|
|
|
p38 (pT180) Antibody |
20-abx009863 |
Abbexa |
-
EUR 376.80
-
EUR 560.40
-
EUR 243.60
|
|
|
AIMP2/p38 Antibody |
DF12048 |
Affbiotech |
200ul |
EUR 420 |
p38 alpha-MAPK14 |
RA15053 |
Neuromics |
100 ug |
EUR 631.2 |
p38 Antibody (MAPK14) |
F50496-0.08ML |
NSJ Bioreagents |
0.08 ml |
EUR 140.25 |
Description: P38 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. |
p38 Antibody (MAPK14) |
F50496-0.4ML |
NSJ Bioreagents |
0.4 ml |
EUR 322.15 |
Description: P38 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. |
p38 Blocking Peptide |
20-abx061736 |
Abbexa |
|
|
|
p38 Blocking Peptide |
20-abx062080 |
Abbexa |
|
|
|
p38 Blocking Peptide |
20-abx161932 |
Abbexa |
|
|
|
P38 (411 - 425), M. leprae |
5-01677 |
CHI Scientific |
4 x 1mg |
Ask for price |
p38 Polyclonal Antibody |
ABP52112-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182 |
p38 Polyclonal Antibody |
ABP52112-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182 |
p38 Polyclonal Antibody |
ABP52112-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182 |
p38 Polyclonal Antibody |
ABP52113-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323 |
p38 Polyclonal Antibody |
ABP52113-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323 |
p38 Polyclonal Antibody |
ABP52113-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323 |
p38 Polyclonal Antibody |
ABP53838-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180 |
p38 Polyclonal Antibody |
ABP53838-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180 |
p38 Polyclonal Antibody |
ABP53838-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180 |
p38 Polyclonal Antibody |
ABP53839-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182 |
p38 Polyclonal Antibody |
ABP53839-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182 |
p38 Polyclonal Antibody |
ABP53839-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182 |
p38 Polyclonal Antibody |
ABP57354-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38 |
p38 Polyclonal Antibody |
ABP57354-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38 |
p38 Polyclonal Antibody |
ABP57354-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38 |
p38 Polyclonal Antibody |
41305-100ul |
SAB |
100ul |
EUR 302.4 |
p38 Polyclonal Antibody |
41305-50ul |
SAB |
50ul |
EUR 224.4 |
p38 Polyclonal Antibody |
41306-100ul |
SAB |
100ul |
EUR 302.4 |
p38 Polyclonal Antibody |
41306-50ul |
SAB |
50ul |
EUR 224.4 |
p38 Polyclonal Antibody |
ES4837-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
p38 Polyclonal Antibody |
ES4837-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
p38 Polyclonal Antibody |
ES4838-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
p38 Polyclonal Antibody |
ES4838-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
p38 Polyclonal Antibody |
ES8347-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA |
p38 Polyclonal Antibody |
ES8347-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA |
p38 Polyclonal Antibody |
ES3111-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
p38 Polyclonal Antibody |
ES3111-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
p38 Polyclonal Antibody |
ES3112-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
p38 Polyclonal Antibody |
ES3112-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
Mouse P38 Mitogen-activated Protein Kinase (MAPK P38) CLIA Kit |
abx197397-96tests |
Abbexa |
96 tests |
EUR 990 |
|
Mouse MAPK P38(P38 Mitogen-activated Protein Kinase) ELISA Kit |
EM1199 |
FN Test |
96T |
EUR 628.92 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.75 ng/ml |
CMV Antigen (p65+p38+pp150) |
E61Y00202 |
EnoGene |
1mg |
EUR 840 |
p38 MAPK Rabbit pAb |
A5521-100ul |
Abclonal |
100 ul |
EUR 369.6 |
p38 MAPK Rabbit pAb |
A5521-200ul |
Abclonal |
200 ul |
EUR 550.8 |
p38 MAPK Rabbit pAb |
A5521-20ul |
Abclonal |
20 ul |
EUR 219.6 |
p38 MAPK Rabbit pAb |
A5521-50ul |
Abclonal |
50 ul |
EUR 267.6 |
p38 MAPK Rabbit mAb |
A4771 |
Abclonal |
20 μL |
EUR 18 |
p38 MAPK Rabbit pAb |
A10832-100ul |
Abclonal |
100 ul |
EUR 460.8 |
p38 MAPK Rabbit pAb |
A10832-200ul |
Abclonal |
200 ul |
EUR 664.8 |
p38 MAPK Rabbit pAb |
A10832-20ul |
Abclonal |
20 ul |
EUR 219.6 |
p38 MAPK Rabbit pAb |
A10832-50ul |
Abclonal |
50 ul |
EUR 318 |
p38 MAPK Rabbit pAb |
A14401-100ul |
Abclonal |
100 ul |
EUR 369.6 |
p38 MAPK Rabbit pAb |
A14401-200ul |
Abclonal |
200 ul |
EUR 550.8 |
p38 MAPK Rabbit pAb |
A14401-20ul |
Abclonal |
20 ul |
EUR 219.6 |
p38 MAPK Rabbit pAb |
A14401-50ul |
Abclonal |
50 ul |
EUR 267.6 |
p38 MAPK Rabbit pAb |
A11340-100ul |
Abclonal |
100 ul |
EUR 369.6 |
p38 MAPK Rabbit pAb |
A11340-200ul |
Abclonal |
200 ul |
EUR 550.8 |
p38 MAPK Rabbit pAb |
A11340-20ul |
Abclonal |
20 ul |
EUR 219.6 |
p38 MAPK Rabbit pAb |
A11340-50ul |
Abclonal |
50 ul |
EUR 267.6 |
p38 MAPK Rabbit pAb |
A8038-100ul |
Abclonal |
100 ul |
EUR 369.6 |
p38 MAPK Rabbit pAb |
A8038-200ul |
Abclonal |
200 ul |
EUR 550.8 |
p38 MAPK Rabbit pAb |
A8038-20ul |
Abclonal |
20 ul |
Ask for price |
This longer-term strategy would provide a deeper pool of drug choices for future-proofing against acquired drug resistance. Second, there will be further viral threats, which will inevitably evade existing vaccines. This will require a coherent therapeutic strategy which pharmacology and pharmacologists are best placed to provide.
Hunting coronavirus SARS-CoV-2 (2019-nCoV): from laboratory testing back to basic research.
The rapid spread of coronavirus disease COVID-19 in many countries causes citizens of daily inconvenience, and even life-threat for elderly population. The invasion of the main pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; 2019-nCov), into human body causes different levels of impact to various patients. One of the most important issues for COVID-19 is how to defend this virus with the ability to foresee the infected targets.
Thus, we maintain the quarantined essentially as for as others saved from COVID-19. So far, the routine laboratory test to confirm whether infected by SARS-CoV-2/2019-nCov or not is through rRT-PCR (qPCR) with certain sequence regions that recognize SARS-CoV-2/2019-nCoV RNA genome.
The heavy loading of rRT-PCR (qPCR) machine and handling labor have tight-packed the instruments as well as the man power almost in every country. Therefore, the alternative approaches are eagerly waiting to be developed. In this review article, we sort out some state-of-the-art novel approaches that might be applied for a fast, sensitive and precise detection of SARS-CoV-2/2019-nCov not only to help the routine laboratory testing but also to improve effective quarantine.